Nilda Gallardo & Antonio Andrés
Professors of Biochemistry and Molecular Biology
Faculty of Chemical Sciences and Technologies, University of Castilla-La Mancha; Health Research Institute of Castilla-La Mancha (IDISCAM), Ciudad Real, Spain
Our group aims to understand how diminished or deficient brain leptin signaling in normal-weight, leptin-sensitive adult rats is associated with hypothalamic nucleus-specific alterations that induce changes in peripheral tissues, including the liver, pancreas, and adipose tissue, thereby mimicking the metabolic alterations associated with aging, including the development of insulin and leptin resistance. We also investigate whether central leptin deficiency is associated with hypothalamic nucleus-specific alterations in protein and lipid composition, as well as with microglial activation and proliferation and neuroinflammation.
